![]() This enzyme normally catalyzes the addition of a phosphate to a mannose sugar attached to a protein destined for the lysosome. For example, inclusion cell (I-cell) disease arises from a defective phosphotransferase in the Golgi. Improper glycosylation or sugar modification patterns can result in the failure of proteins to reach the correct cellular compartment. The oligosaccharides that are attached to proteins may also determine their cellular destinations. The types of oligosaccharides found on the surface of blood cells is a determinant of blood type. On the cell surface, glycoproteins with distinctive oligosaccharides attached establish the identity of each cell. Oligosaccharides often function as identity markers, both of cells and proteins.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |